Toxicology Reports has published a new research paper by C&IH, “Habit of Elongate Amphibole Particles as a Predictor of Mesothelial Carcinogenicity.” Authored by C&IH Director of Research and Development,
Dr. Andrey Korchevskiy along with C&IH Senior Scientific Advisor and Professor Emerita of the University of Maryland,
Dr. Ann Wylie, the paper is currently available online at
Science Direct and will be included in the upcoming June 2025 volume of
Toxicology Reports. As described in the paper, the authors “utilized new modeling and statistical approaches to the analysis of toxicological characteristics for elongate mineral particles” and conclude “the habit of amphibole particles is predictive of biological behavior that can be estimated from the dimensional data for the particles.” The paper provides convincing evidence that non-asbestiform tremolite particles (i.e., cleavage fragments) cannot be implicated in increasing mesothelioma rate in workers and populations. The results are confirmed by data from human epidemiological studies and animal experiments based on rigorous mathematical modeling.