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The research builds on one of the most important occupational cohorts in asbestos epidemiology, encompassing 11,379 workers from the Québec chrysotile industry. By integrating historical dust (midget-impinger) and fiber (phase-contrast microscopy) measurements, the authors produced refined cumulative exposure estimates. Mean values ranged from approximately 528 to 979 f/cc-years, depending on the model used.
Results confirmed that mesothelioma potency factors for non-textile chrysotile remain consistent with previous analyses (≈ 0.0011 % – 0.0014 %). The study further examined potential threshold ranges for cumulative exposure, identifying the lowest mesothelioma case near 68 f/cc-years and modeling thresholds between ~36 and 66 f/cc-years.
These findings strengthen the quantitative foundation for risk assessment models and exposure-response evaluation. The authors note that while threshold hypotheses remain debated, continued refinement of exposure data enhances transparency and scientific rigor in occupational health policy.
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