A new research paper by C&IH called “The Empirical Metric of Mesothelial Carcinogenicity for Carbon Nanotubes and Elongate Mineral Particles” was recently published by the journal
Inhalation Toxicology. The article presents a comprehensive analysis of how the physical dimensions and biopersistence of elongate mineral particles (EMPs) and high aspect ratio nanomaterials (HARNs), such as carbon nanotubes (CNTs), influence their potential to cause mesothelioma. The study introduced a new quantitative metric – dimensional coefficient of carcinogenicity (DCC) – that allows to efficiently distinguish between mesotheliomagenic and non-mesotheliomagenic particles. The metric works well for both carbon nanotubes and mineral particles, proving that a general theory of mesothelial carcinogenesis can be proposed for all types of natural or engineered elongate structures. It was demonstrated that mesotheliomagenic potency of amphibole cleavage fragments is expected to be negligible based on the new metric. Authored by C&IH Director of Research and Development
Dr. Andrey Korchevskiy, and C&IH Senior Scientific Advisor
Dr. Ann Wylie, the paper is available
online through the
Inhalation Toxicology.
