The Journal
Frontiers in Toxicology published a new study by C&IH titled
“Critical values for dimensional parameters of mesotheliomagenic mineral fibers: evidence from the dimensions and rigidity of MWCNT.” The study investigates the relationship between the physical characteristics of mineral fibers and their potential to induce mesothelioma, a type of cancer associated with exposure to asbestiform particles. A new parameter (rigidity index) was introduced to demonstrate the role of mechanistic factors in potential biological effects of elongate particles. Experimental data on multiwalled carbon nanotubes (MWCNTs) was collected from literature and used for determination of critical rigidity threshold for potential health effects. The findings suggest that the direct interaction between elongate structures and mesothelial cells, particularly the piercing of cell membranes by thin, rigid particles, plays a significant role in the initiation of inflammation and carcinogenesis, highlighting the importance of controlling the diameter and rigidity of MWCNTs in their design to mitigate potential health risks. It was demonstrated that low rigidity of chrysotile and fibrous talc can play a role in comparatively low carcinogenicity of these minerals. The paper is authored by C&IH Senior Scientific Advisor
Dr. Ann Wylie and C&IH Director of Research and Development
Dr. Andrey Korchevskiy and is available
online through the
Frontiers in Toxicology.
